plasmacytoid dendritic cells sense self-dna coupled with antimicrobial peptide plasmacytoid dendritic cells - plasmacytoid-dendritic-cells-sense-self-dna-coupled-with-antimicrobial-peptide how pDCs might respond to apoptotic cell-expressed self-antigens The Intriguing Mechanism: How Plasmacytoid Dendritic Cells Sense Self-DNA Coupled with Antimicrobial Peptide

neurogan-copper-peptides The intricate dance of the immune system often involves recognizing ‘self’ from ‘non-selfEuropean Journal of Dermatology - Plasmacytoid dendritic ....’ However, in certain pathological conditions, the lines between these can blur, leading to inappropriate immune responsesThe data uncover a fundamental role of an endogenousantimicrobial peptidein breaking innate tolerance toself-DNAand suggest that this pathway may drive .... A fascinating area of research focuses on plasmacytoid dendritic cells (pDCs) and their extraordinary ability to sense self-DNA when it becomes coupled with antimicrobial peptides. This phenomenon plays a significant role in the development and exacerbation of autoimmune diseases, particularly those affecting the skin作者：R Lande·2011·被引用次数：1590—These NETs, which contain antimicrobial peptides complexed with self-DNA, activate plasmacytoid dendritic cells, leading to interferon release and furtherment ....

At the forefront of this discovery is the seminal work by R. Lande and colleagues, which revealed that plasmacytoid dendritic cells (pDCs) are not merely passive bystanders in the immune landscape. Instead, these specialized cells act as potent sentinels. Their primary role is to sense foreign invaders, such as viral and microbial DNA, typically through endosomal Toll-like receptors like TLR7 and TLR9. This recognition triggers the production of crucial type I interferons, essential for mounting an effective defense.

However, the groundbreaking research, including studies published in *Nature* in 2007, unveiled a critical caveat: plasmacytoid dendritic cells can also be activated by endogenous or "self" componentsSelf-RNA–antimicrobial peptide complexes activate human .... This activation is not inherent to the self-DNA alone, which normally arises from dying cells and is rendered non-stimulatory. Instead, the key orchestrator is a class of molecules known as antimicrobial peptides.

One of the most prominent antimicrobial peptides implicated in this process is LL37, also known as the human cathelicidin antimicrobial peptide (CAMP). Research has demonstrated that LL37, secreted by keratinocytes in lesional skin or released by neutrophils, possesses the remarkable ability to bind to self-DNA. This binding is crucial because it effectively "couples" the self-DNA with the antimicrobial peptide, transforming the normally silent self-DNA into a potent immune trigger.Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide· Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA–peptide ...

The self-DNA coupled with antimicrobial peptide complexes, particularly the self-DNA-peptide complexes, are then recognized by pDCs2007年9月16日—Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. 0. 57.021. Publication Hot Score (2-year base): .... This recognition leads to the activation of these plasmacytoid dendritic cells. This activation cascade is particularly relevant in conditions like psoriasis. Studies have shown that pDC activation in psoriatic skin is significantly driven by the antimicrobial peptide LL37. This interaction underscores the importance of understanding how pDCs sense self-DNA in the context of chronic inflammation.作者：C Conrad·2009·被引用次数：93—Normally, pDCs fail tosensehost-derivedself-nucleic acids but do so whenself-nucleic acids form complexes with endogenousantimicrobial peptidesproduced in ...

Furthermore, the role of antimicrobial peptides extends beyond LL37. Other antimicrobial peptides, such as human β-defensin 3 (hBD3), have also been shown to enhance the recognition of self-DNA by human plasmacytoid dendritic cells, albeit through different pathways, such as amplifying the TLR9-mediated response. The ability of these cationic antimicrobial peptides to cooperate with self-DNA in autoimmune skin diseases highlights a shared mechanistic theme.作者：Y Döring·2012·被引用次数：502—Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007; 449: 564– 569. Crossref · PubMed · Google Scholar.

This mechanism of plasmacytoid dendritic cells sensing self-DNA coupled with antimicrobial peptide has profound implications. It provides a crucial insight into how the immune system, which is designed to tolerate self, can paradoxically launch an attack against its own tissues. This process breaks down innate tolerance to self-DNA, contributing to the pathogenesis of autoimmune conditions like psoriasis and systemic lupus erythematosus. For instance, neutrophils, through their release of self-DNA-peptide complexes containing antimicrobial peptides, can activate pDCs, leading to the production of interferons and perpetuating inflammation.Cytosolic sensing of extracellular self-DNA transported into ...

While pDCs normally fail to sense self-nucleic acids, their hypersensitivity arises precisely when these self-nucleic acids form complexes with endogenous antimicrobial peptides作者：EY Lee·被引用次数：86—Neutrophils activateplasmacytoid dendritic cellsby releasingself-DNA-peptidecomplexes in systemic lupus erythematosus. Sci. Transl. Med. 3, 73ra19–73ra19 ( .... This intricate interaction emphasizes the dual role of antimicrobial peptides: while vital for host defense against pathogens, they can also inadvertently trigger autoimmune responses by activating immune cells towards self-componentsHelical antimicrobial peptides assemble into protofibril ....

Understanding how pDCs might respond to apoptotic cell-expressed self-antigens in the absence of autoantibodies or antimicrobial peptides remains an area of ongoing investigation2012年11月1日—Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. ... dendritic cells by releasing self-DNA-peptide complexes .... However, the established pathway involving self-DNA and antimicrobial peptides serves as a critical example of how the immune system can become misdirected, leading to inflammatory and autoimmune diseases. The ability of plasmacytoid dendritic cells to sense these complexes is a double-edged sword, crucial for pathogen defense but a potential driver of autoinflammation when self-components are involved.

In summary, the research on plasmacytoid dendritic cells (pDCs) sensing self-DNA coupled with antimicrobial peptide reveals a sophisticated immune mechanism that, under pathological circumstances, contributes to autoimmune disorders.Plasmacytoid dendritic cells sense self-DNA coupled with ... The identification of antimicrobial peptides like LL37 as key mediators in this process has provided invaluable insights into the pathogenesis of skin diseases and offers potential targets for therapeutic intervention in autoimmune inflammatory conditionsNeutrophils Activate Plasmacytoid Dendritic Cells by ... - PMC. The ability of pDCs to sense this specific molecular pairing is a cornerstone in understanding how the immune system navigates the complex boundary between self and non-self.