plp peptide PLP is a highly conserved hydrophobic protein of 276 to 280 amino acids - Peptide157 peptides Understanding the Significance of PLP Peptide in Neuroimmunology and Beyond

Peptide141 The PLP peptide refers to specific fragments derived from Myelin Proteolipid Protein (PLP), a crucial component of the central nervous system (CNS) myelin sheath. These peptides have garnered significant research interest due to their roles in neuroinflammation and their utility as tools in experimental modelsPLP139-151peptidesare widely used to induce Experimental Autoimmune Encephalomyelitis (EAE), a model for studying multiple sclerosis and other autoimmune .... Understanding the various PLP peptides, particularly the well-studied PLP (139-151) peptide, offers valuable insights into the intricate mechanisms of the nervous system and autoimmune disorders.

PLP itself is the major myelin protein from the central nervous system, a highly conserved hydrophobic protein, typically comprising 276 to 280 amino acids. It plays an indispensable role in the formation and maintenance of the myelin's multilamellar structure. The Proteolipid protein (PLP) gene encodes this essential protein, and mutations in this gene are linked to various neurological conditions. Beyond its structural function, research into recent advances in understanding the role of myelin proteolipid protein (PLP) suggests it also acts as a significant antigenic target in demyelinating diseases.

One of the most extensively studied PLP peptides is the PLP (139-151) peptide. This particular fragment, corresponding to amino acid residues 139 to 151 of myelin proteolipid protein, is immunogenic and has been widely used to induce Experimental Autoimmune Encephalomyelitis (EAE) in laboratory animals, notably in SJL/J mice. EAE is a widely recognized animal model for studying multiple sclerosis (MS) and other autoimmune demyelinating diseases. Specifically, the PLP (139-151) peptide is commonly used to induce experimental autoimmune encephalomyelitis (EAE) in SJL/J mice, serving as a critical tool for investigating the autoimmune responses targeting myelin.PLP (139-151) · 分子别名. Myelin proteolipid protein (139-151); Proteolipid protein (139-151) · 表达序列. HSLGKWLGHPDKF · 分子量. 1521.74 · 纯度. >95% · 溶解方法. This PLP (139-151) peptide is known to induce severe clinical and histological experimental autoimmune conditions, making it invaluable for understanding the pathogenic processes of neuroinflammation. Moreover, variations like the PLP (139-151) C140S mutant, where cysteine at position 140 is substituted with serine, can also induce severe, acute experimental allergic encephalomyelitis in mice, offering nuances in studying specific immune responses. Some sources also refer to PLP (139-151) as linPLP or Proteolipid Peptide (139-151), highlighting its synonymy in scientific literature. The typical purity of these synthetic peptides is often greater than 95%, with sequences like HSLGKWLGHPDKF being verifiable.PLP (139-151) peptide

Other notable PLP peptides explored in research include PLP (180-199) is a biological active peptide and Myelin PLP (178-191). The PLP (180-199) is a biological active peptide, representing amino acids 180-199 of the myelin proteolipid protein, and similarly, Myelin PLP (178-191), encompassing amino acids 178 to 191, is recognized as an immunodominant encephalitogenic epitope in SJL mice. These peptides also serve as important immune epitopes due to their ability to bind to specific human leukocyte antigen (HLA) molecules, such as HLA-DR2, which is genetically linked to an increased susceptibility to multiple sclerosis in certain populations. Research has shown that other PLP peptides, such as PLP peptides like PLP104–117, PLP142–153, and PLP190–209, are also encephalitogenic in animals, acting as known immune epitopes that can bind to HLA-DR2. Furthermore, PLP139-151 peptides are widely used to induce Experimental Autoimmune Encephalomyelitis (EAE) models, aiding in the study of diseases like multiple sclerosis.ThePLP[139-151]peptidefrom the myelin proteolipid protein (PLP) has been found to be highly immunogenic in inducing experimental allergic ...

The availability of these specific peptides has facilitated advancements in numerous areas of researchT cell response to two immunodominant proteolipid protein .... For instance, PepTivator® PLP, human, represents a pool of lyophilized peptides primarily consisting of 15-mer sequences with overlapping amino acid residues, covering the complete human PLP sequence.T cell response to two immunodominant proteolipid protein ... This product is designed for use in immunological studies involving human cells. The precise amino acid composition and molecular weight are key parameters for researchers sourcing these materials.This is amino acids 178 to 191 fragment of the proteolipid protein (PLP), an immunodominant encephalitogenic epitope in SJL mice. For example, the PLP (139-151) peptide has a molecular weight of approximately 1521.7 Da.

Beyond autoimmune research, the term PLP peptide can also refer to different entities. For instance, there are PawL-Derived peptides (PLPs), discovered in 2021, a subfamily of orbitides produced during the maturation of seed storage precursors. While unrelated to myelin, the nomenclature highlights the potential for ambiguity and the importance of context when discussing PLP peptide[Ser 140 ]-PLP (139-151).

In summary, the PLP peptide, particularly its PLP (139-151) variant, is a cornerstone in the study of neuroinflammatory and autoimmune conditions like multiple sclerosis. Its ability to reliably induce EAE in animal models provides researchers with a powerful tool to investigate disease pathogenesis, test therapeutic interventions, and understand the complex interplay between the immune system and the central nervous system[Ser 140 ]-PLP (139-151). The ongoing exploration of various PLP peptides continues to deepen our understanding of PLP and its multifaceted roles in health and disease.