creka peptide CREKA Peptide - creative-bio-peptides CREKA-modified nanoprobes demonstrate superior site retention and accumulation Advancing Biomedical Applications with the CREKA Peptide

creatine-peptide-muscletech The CREKA peptide, a pentapeptide with the specific sequence Cys-Arg-Glu-Lys-Ala (CREKA), is emerging as a significant tool in various biomedical applications, particularly in targeted drug delivery and imaging. This unique peptide demonstrates remarkable properties, including its ability to self-assemble into functional nanostructures and its selective binding to specific biological targets作者：B Zhang·2016·被引用次数：153—A self-amplified drug delivery system was developed for tumor photothermal therapy (CMWNTs-PEG) using multi-walled carbon nanotubes (MWNTs). Research indicates that CREKA is a less immunogenic, low-cost fibrin-binding peptide, making it an attractive alternative to larger biomolecules like antibodies for precise targeting.

A key characteristic of the CREKA peptide is its high affinity for fibrin and fibrin-fibronectin complexes. These complexes are often found overexpressed in pathological sites, such as tumor microenvironments and sites of thrombosis or myocardial ischemia-reperfusion injury. This specificity allows for the precise localization of therapeutic agents or imaging probes to disease-affected areas.作者：J Zhao·2015·被引用次数：117—A small nanoparticle drug delivery system was developed byconjugating fibrin-binding peptide CREKAto Polyamidoamine (PAMAM) dendrimer. Studies have shown that CREKA-modified nanoprobes demonstrate superior site retention and accumulation, which is crucial for effective diagnosis and treatment.

Targeted Therapies and Imaging

The application of the CREKA peptide in cancer treatment is a prominent area of research.Recent advances of CREKA peptide-based nanoplatforms ... By conjugating it to various nanocarriers, such as lipid nanocarriers, dendrimers, or nanoparticles, researchers can create sophisticated drug delivery systems. For instance, multifunctional CREKA peptide conjugated lipid nanocarriers have been developed for synergistically acting drugs like Noscapine and Doxorubicin, specifically targeting cancer cells via tumor-homing peptide CREKA. The conjugating fibrin-binding peptide CREKA strategy enhances the efficacy of treatments like Doxorubicin-mediated apoptosis, as demonstrated by increased effectiveness compared to non-conjugated nanoparticles.CREKA peptide | Self-assembling peptides

Beyond cancer, the CREKA peptide has shown promise in targeting other conditions. It can target tumors, enabling accurate experimental tracking of ultrasmall breast cancer metastases. Its affinity for fibrin also makes it valuable for developing targeted therapies for conditions like myocardial ischemia-reperfusion injury and atherosclerosis.作者：MS Hajizade·2024·被引用次数：6—In recent years, thepeptideCys-Arg-Glu-Lys-Ala (CREKA), which specifically detects fibrin–fibronectin complexes, has been utilized in the development of a ... Furthermore, the CREKA peptide is recognized as a pentapeptide that can target tumors and is considered a desirable targeting ligand due to its strong targeting ability for overexpressed fibrin in different disease models.

Nanotechnology and Self-Assembly

The ability of the CREKA peptide to self-assemble into functional nanostructures is another significant aspect driving its applicationCREKA peptide | 自组装肽. As a self-assembling peptide (SAPs), it can form nanostructures that can encapsulate or carry therapeutic payloads. This self-assembly property, coupled with its targeting capabilities, opens avenues for novel drug delivery systems. For example, CREKA peptide-conjugated dendrimer nanoparticles have been developed using Polyamidoamine (PAMAM) dendrimers, forming a small nanoparticle drug delivery system.Targeting Cancer Cells via Tumor-homing Peptide CREKA ...

Research and Development

Ongoing research continues to explore the full potential of the CREKA peptide.作者：A Puiggalı́-Jou·2020·被引用次数：41—Cys-Arg-Glu-Lys-Ala (CREKA) is an important fibrin-homing pentapeptide that has been extensively demonstrated for diagnoses and therapies ... Recent advances in CREKA peptide-based nanoplatforms in biomedical applications highlight its versatility. Studies have also investigated its conformational preferences and its use in combination with other materials, such as boron nitride nanotubes, to create effective targeted therapies. The characterization of the peptide, including its UV chromatogram of CREKA peptide recorded at 220 nm with a purity of 94%, and its trifluoroacetic acid form, a trifluoroacetic acid form of a short peptide, provides essential data for its synthesis and application.

In conclusion, the CREKA peptide represents a significant advancement in targeted biomedical interventions. Its specific binding properties, low immunogenicity, and self-assembling characteristics make it a valuable tool for developing next-generation diagnostic and therapeutic strategies for a range of diseasesCREKA peptide acetate|Cas#.